Official Website for ASCENIV (immune globulin intravenous, human)

Select donor profile

The only available IVIG product made with a proprietary method for donor screening AND plasma pooling

Quality in every vial

Every vial includes a broad spectrum of antibodies, taken from plasma pooled from at least 1,000 donors

Unique IVIG composition

ASCENIV is the only IVIG that uses ADMA's patented methodologies for donor screening and plasma pooling. ASCENIV not only meets standard IVIG criteria, but also includes plasma from donors selected for their antibody levels for certain respiratory pathogens

Zero bacterial infections. No patient taking ASCENIV had a serious bacterial infection

Zero hospitalizations. No patient taking ASCENIV was hospitalized due to a PI-related infection

Only 1.7 missed work or school days per year

Demonstrated safety profile

The most common side effects in the ASCENIV clinical trial were:

Headache
Sinus inflammation (sinusitis)
Diarrhea
Intestinal lining inflammation caused by virus (gastroenteritis)
Common cold (nasopharyngitis)
Upper respiratory tract infection
Bronchitis
Nausea

These are not all the possible side effects of ASCENIV. If you experience the above or
any other side effects while taking ASCENIV, call your healthcare provider immediately
or dial 911.

You are encouraged to report side effects of prescription drugs to ADMA Biologics at
1-800-458-4244 or the FDA. Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.

“I'm so grateful that I have ASCENIV in my corner”

MEET LISA MARIE, 55-year-old nurse, married with a blended family of 5 children, living with a rare blood vessel disease in addition to PI

Read Lisa Marie’s full story

Hide full story

MY STORY

For as long as I can remember, whenever I got sick, I would get very sick. One year, I had strep throat 13 times.

MY PI DIAGNOSIS

Despite my complicated health history, I was never quite sure what was wrong with me. At age 43, I was diagnosed with PI. I tried 2 other immunoglobulin treatments before switching to ASCENIV.

MY EXPERIENCE WITH ASCENIV

I now receive monthly infusions. I already can tell it’s made a major difference in my health.

As a nurse, I know the importance of protecting my immune system, especially being immunocompromised. I can go on trips with my friends and family – none of which would have been possible before beginning treatment.

I can do more and be more present for things that I had to give up because of PI.

“Thanks to ASCENIV, I got my life back”

MEET LYNNE, 65-year-old caregiver, married with 2 children, who works with people who have developmental disabilities

Read Lynne’s full story

Hide full story

MY STORY

I had always felt like I had something going on with my health. My frequent absences due to sickness created challenges at work.

MY PI DIAGNOSIS

I received excellent care from my allergist and primary care physician, but I still was never consistently healthy.

After years of trying to determine what was wrong, I was diagnosed with PI at age 62.

MY EXPERIENCE WITH ASCENIV

My immunologist then prescribed me ASCENIV, and I’ve been receiving monthly infusions for 2 years. After being on treatment for a little while, I realized I was healthier for longer periods of time and spending less time resting or recovering from illnesses.

I’m able to do more of what I love and spend more time with the people I love.

“Before ASCENIV, I kind of just existed”

MEET REGINA, 50-year-old elementary math tutor, married with 3 children, one of whom also has PI

Read Regina’s full story

Hide full story

MY STORY

My first encounter with PI was through my daughter. At 10 years old, she was finally diagnosed with the condition after having been sick with nonstop infections for 2 years.

I, too, had always struggled to recover from any type of sickness, even after taking antibiotics. But before my daughter became ill, I’d never heard of PI.

MY PI DIAGNOSIS

When I began to experience recurrent infections like my daughter did, I met with her immunologist. Soon after, I was diagnosed with PI at age 48 and was initially prescribed an immune globulin treatment.

My doctor then switched me to ASCENIV, and after a few months of treatment, I noticed a significant improvement in my health.

MY EXPERIENCE WITH ASCENIV

I feel better, and I’m back to living the life that I want.

I used to miss so much work due to being sick, and even when I was at work, I rarely felt completely well. But now, I don’t remember the last time I needed to take a sick day.

I’m so glad that my daughter and I received the diagnoses we needed. And I’m grateful that I found a way to get my life back through ASCENIV.

“Thanks to ASCENIV, the old me is coming back”

MEET SHERRY, 51-year-old nurse, married with a daughter in college

Read Sherry’s full story

Hide full story

MY STORY

I didn’t think anything was wrong at first. I always thought I sufferer from constant infections because I worked in a nursing home where illnesses could easily be spread. But even after I moved to working in hospice care, I continued to get sick frequently.

MY PI DIAGNOSIS

After nine months of searching for the right diagnosis, my doctors told me I had PI. Over the next 16 years, I tried many different treatments that temporarily helped my symptoms but didn’t quite sustain me for as long as I needed. That all changed when I started ASCENIV.

MY EXPERIENCE WITH ASCENIV

Now, I can enjoy traveling, hiking, and spending time with my husband and loved ones without being worn out for days afterward. Living with primary immunodeficiency can be challenging, but for me, ASCENIV makes it easier. I’m glad my doctors helped me find the treatment that’s right for me.

Important Safety Information for ASCENIV™

WARNING: RISK OF BLOOD CLOTS (THROMBOSIS), POOR KIDNEY FUNCTION, AND INABILITY TO FILTER WASTE FROM KIDNEYS. BLOOD CLOTS MAY OCCUR WITH INTRAVENOUS IMMUNE GLOBULIN PRODUCTS, INCLUDING ASCENIV.

Before taking ASCENIV, talk to your doctor if you:

Are of advanced age
Are unusually sedentary (long periods of sitting down or inactive)
Are taking estrogen-containing medicines (birth control pills, hormone replacement therapy)
Have a permanent intravenous (IV) catheter
Have hyperviscosity of the blood (diseases such as multiple myeloma or other causes of elevated proteins in the blood)
Have cardiovascular (heart) problems or previous history of stroke

Thrombosis may occur even if you do not have any risk factors.

Serious kidney problems and death can also happen in certain patients who receive such products.

If you are at high risk of thrombosis or kidney problems, your doctor should adjust the dose of ASCENIV and will monitor you for signs and symptoms of thrombosis and viscosity, as well as kidney function.

What is ASCENIV (immune globulin intravenous, human-slra)?

ASCENIV (immune globulin intravenous, human-slra) is a prescription medicine to help adults and adolescents (12 to 17 years old) with primary immunodeficiency fight and prevent infections.
ASCENIV is for intravenous administration only. ASCENIV is made from healthy human blood/plasma.

Who should not use ASCENIV?

ASCENIV should not be used if you had a severe allergic reaction to human immune globulin or if you have been told by a doctor that you are immunoglobulin A (IgA)-deficient and have developed antibodies to IgA and hypersensitivity after exposure to a previous plasma product.

What are possible warnings and precautions with taking ASCENIV?

Hypersensitivity. Severe allergic reactions may occur with immune globulin products, including ASCENIV. If you have a severe allergic reaction, stop the infusion immediately and get medical attention. ASCENIV contains IgA. If you have known antibodies to IgA, you may have a greater risk of developing potentially severe allergic reactions.

If you take ASCENIV or a similar immune globulin product, you could experience a serious and life-threatening blood clot (thromboembolism). This may include pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness, or weakness on one side of the body. If you are at risk, your doctor may decide to adjust the dose of ASCENIV. Your doctor will monitor you for any signs or symptoms of blood clots or poor blood flow in your arteries.

Always tell your doctor immediately if your medical history is similar to what is described here, and especially if you experience any of these symptoms while taking ASCENIV.

Kidney problems or failure. Kidney problems, kidney failure, and death may occur with use of human immune globulin products, especially those containing sucrose (sugar). ASCENIV does not contain sucrose.

If you have kidney disease or diseases with kidney involvement, your doctor should perform a blood test to assess your hydration level and kidney function before beginning immune globulin treatment and at appropriate intervals thereafter. If your doctor determines that kidney function is worsening, they may discontinue treatment. If your doctor determines you be at risk, they may start your dose of ASCENIV at a safe level.

People taking human immune globulin products, including ASCENIV, may experience hyperproteinemia (high levels of protein in the blood), hyponatremia (low levels of sodium in the blood), and hyperviscosity (poor blood flow). Your doctor may perform certain blood tests and monitor you to minimize any of the above risks.

Aseptic meningitis syndrome (AMS). Aseptic meningitis is a non-infectious inflammation of the membranes that cover the brain. It causes a severe headache, which may occur with human immune globulin treatment, including ASCENIV. AMS usually happens within a few hours to 2 days after treatment. AMS is more commonly associated with higher doses of treatment and/or after rapid infusion. Your doctor may perform a neurological exam, including spinal tap (sampling fluid which surrounds the spinal cord) to evaluate your condition and to rule out other causes of meningitis.

Hemolysis. Hemolysis refers to the destruction of red blood cells. Immune globulin products, including ASCENIV, may contain certain antibodies that can result in the rupturing of red blood cells. Your doctor should monitor you for signs and symptoms of hemolysis, which may include additional confirmation tests.

Taking intravenous human immune globulin products may cause a build up of fluid in the lungs (pulmonary edema) that is unrelated to heart problems. Your doctor should monitor you for lung-related side effects and may conduct appropriate tests that can detect the presence of certain white blood cells (anti-neutrophils) in the drug or your blood. If needed, your doctor may decide to use oxygen or other respiratory methods to help your breathing.

Transmissible infectious agents. Because ASCENIV is made from human blood, it may carry a risk of transmitting infectious agents such as viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. Your doctor will report to the manufacturer any cases of suspected infections spread by the product.

Interference with lab tests. Because ASCENIV contains a variety of antibodies that are infused into your body, blood tests to determine antibody levels may provide misleading interpretations. Be sure to always tell your doctor, nurse, or lab technician of any medicines you are taking and that you are using ASCENIV.

Interactions with medicines. ASCENIV can make vaccines (like measles, mumps, rubella, and chicken pox vaccines) less effective in your body. Before you get any vaccines, tell your healthcare provider that you take ASCENIV.

What are other possible side effects of ASCENIV?

In clinical studies of ASCENIV, some patients experienced the following:

Headache
Sinus inflammation (sinusitis)
Diarrhea
Intestinal lining inflammation caused by virus (gastroenteritis)
Common cold (nasopharyngitis)
Upper respiratory tract infection
Bronchitis
Nausea

These are not all the possible side effects of ASCENIV.
Talk to your healthcare provider about any side effect that bothers you or that does not go away.

You are encouraged to report side effects of prescription drugs to the FDA.
Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.

Please Click here for full Prescribing Information for ASCENIV.

Important Safety Information for ASCENIV™

WARNING: RISK OF BLOOD CLOTS (THROMBOSIS), POOR KIDNEY FUNCTION, AND INABILITY TO FILTER WASTE FROM KIDNEYS. BLOOD CLOTS MAY OCCUR WITH INTRAVENOUS IMMUNE GLOBULIN PRODUCTS, INCLUDING ASCENIV.

Before taking ASCENIV, talk to your doctor if you:

Are of advanced age
Are unusually sedentary (long periods of sitting down or inactive)
Are taking estrogen-containing medicines (birth control pills, hormone replacement therapy)
Have a permanent intravenous (IV) catheter
Have hyperviscosity of the blood (diseases such as multiple myeloma or other causes of elevated proteins in the blood)
Have cardiovascular (heart) problems or previous history of stroke

Thrombosis may occur even if you do not have any risk factors.

Serious kidney problems and death can also happen in certain patients who receive such products.

If you are at high risk of thrombosis or kidney problems, your doctor should adjust the dose of ASCENIV and will monitor you for signs and symptoms of thrombosis and viscosity, as well as kidney function.

What is ASCENIV (immune globulin intravenous, human-slra)?

ASCENIV (immune globulin intravenous, human-slra) is a prescription medicine to help adults and adolescents (12 to 17 years old) with primary immunodeficiency fight and prevent infections.

ASCENIV is for intravenous administration only. ASCENIV is made from healthy human blood/plasma.

Who should not use ASCENIV?

ASCENIV should not be used if you had a severe allergic reaction to human immune globulin or if you have been told by a doctor that you are immunoglobulin A (IgA)-deficient and have developed antibodies to IgA and hypersensitivity after exposure to a previous plasma product.

What are possible warnings and precautions with taking ASCENIV?

Hypersensitivity. Severe allergic reactions may occur with immune globulin products, including ASCENIV. If you have a severe allergic reaction, stop the infusion immediately and get medical attention. ASCENIV contains IgA. If you have known antibodies to IgA, you may have a greater risk of developing potentially severe allergic reactions.

If you take ASCENIV or a similar immune globulin product, you could experience a serious and life-threatening blood clot (thromboembolism). This may include pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness, or weakness on one side of the body. If you are at risk, your doctor may decide to adjust the dose of ASCENIV. Your doctor will monitor you for any signs or symptoms of blood clots or poor blood flow in your arteries.

Always tell your doctor immediately if your medical history is similar to what is described here, and especially if you experience any of these symptoms while taking ASCENIV.

Kidney problems or failure. Kidney problems, kidney failure, and death may occur with use of human immune globulin products, especially those containing sucrose (sugar). ASCENIV does not contain sucrose.

If you have kidney disease or diseases with kidney involvement, your doctor should perform a blood test to assess your hydration level and kidney function before beginning immune globulin treatment and at appropriate intervals thereafter. If your doctor determines that kidney function is worsening, they may discontinue treatment. If your doctor determines you be at risk, they may start your dose of ASCENIV at a safe level.

People taking human immune globulin products, including ASCENIV, may experience hyperproteinemia (high levels of protein in the blood), hyponatremia (low levels of sodium in the blood), and hyperviscosity (poor blood flow). Your doctor may perform certain blood tests and monitor you to minimize any of the above risks.

Aseptic meningitis syndrome (AMS). Aseptic meningitis is a non-infectious inflammation of the membranes that cover the brain. It causes a severe headache, which may occur with human immune globulin treatment, including ASCENIV. AMS usually happens within a few hours to 2 days after treatment. AMS is more commonly associated with higher doses of treatment and/or after rapid infusion. Your doctor may perform a neurological exam, including spinal tap (sampling fluid which surrounds the spinal cord) to evaluate your condition and to rule out other causes of meningitis.

Hemolysis. Hemolysis refers to the destruction of red blood cells. Immune globulin products, including ASCENIV, may contain certain antibodies that can result in the rupturing of red blood cells. Your doctor should monitor you for signs and symptoms of hemolysis, which may include additional confirmation tests.

Taking intravenous human immune globulin products may cause a build up of fluid in the lungs (pulmonary edema) that is unrelated to heart problems. Your doctor should monitor you for lung-related side effects and may conduct appropriate tests that can detect the presence of certain white blood cells (anti-neutrophils) in the drug or your blood. If needed, your doctor may decide to use oxygen or other respiratory methods to help your breathing.

Transmissible infectious agents. Because ASCENIV is made from human blood, it may carry a risk of transmitting infectious agents such as viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. Your doctor will report to the manufacturer any cases of suspected infections spread by the product.

Interference with lab tests. Because ASCENIV contains a variety of antibodies that are infused into your body, blood tests to determine antibody levels may provide misleading interpretations. Be sure to always tell your doctor, nurse, or lab technician of any medicines you are taking and that you are using ASCENIV.

Interactions with medicines. ASCENIV can make vaccines (like measles, mumps, rubella, and chicken pox vaccines) less effective in your body. Before you get any vaccines, tell your healthcare provider that you take ASCENIV.

What are other possible side effects of ASCENIV?

In clinical studies of ASCENIV, some patients experienced the following:

Headache
Sinus inflammation (sinusitis)
Diarrhea
Intestinal lining inflammation caused by virus (gastroenteritis)
Common cold (nasopharyngitis)
Upper respiratory tract infection
Bronchitis
Nausea

These are not all the possible side effects of ASCENIV.
Talk to your healthcare provider about any side effect that bothers you or that does not go away.

You are encouraged to report side effects of prescription drugs to the FDA.
Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.

Please Click here for full Prescribing Information for ASCENIV.

COOKIE NOTICE

Watch Patient Stories

Talk to your doctor about whether ASCENIV is right for you

Talk to your doctor about whether ASCENIV is right for you

What is ASCENIV?

Discover the ASCENIV difference

Discover the ASCENIV difference

Select donor profile

Quality in every vial

Unique IVIG composition

Protection you can count on

Results from a 12-month ASCENIV clinical study of 59 adults and adolescents with PI

Zero bacterial infections. No patient taking ASCENIV had a serious bacterial infection

Zero hospitalizations. No patient taking ASCENIV was hospitalized due to a PI-related infection

Only 1.7 missed work or school days per year

Demonstrated safety profile

Learn from others how ASCENIV can make a positive difference when living with PI

Savings and support made simple when starting ASCENIV

Financial assistance with your co-pay costs*

Dedicated support to help you

Important Safety Information for ASCENIV™

WARNING: RISK OF BLOOD CLOTS (THROMBOSIS), POOR KIDNEY FUNCTION, AND INABILITY TO FILTER WASTE FROM KIDNEYS. BLOOD CLOTS MAY OCCUR WITH INTRAVENOUS IMMUNE GLOBULIN PRODUCTS, INCLUDING ASCENIV.Before taking ASCENIV, talk to your doctor if you:

What is ASCENIV (immune globulin intravenous, human-slra)?

ASCENIV (immune globulin intravenous, human-slra) is a prescription medicine to help adults and adolescents (12 to 17 years old) with primary immunodeficiency fight and prevent infections.ASCENIV is for intravenous administration only. ASCENIV is made from healthy human blood/plasma.

Who should not use ASCENIV?

ASCENIV should not be used if you had a severe allergic reaction to human immune globulin or if you have been told by a doctor that you are immunoglobulin A (IgA)-deficient and have developed antibodies to IgA and hypersensitivity after exposure to a previous plasma product.

What are possible warnings and precautions with taking ASCENIV?

Always tell your doctor immediately if your medical history is similar to what is described here, and especially if you experience any of these symptoms while taking ASCENIV.

Kidney problems or failure. Kidney problems, kidney failure, and death may occur with use of human immune globulin products, especially those containing sucrose (sugar). ASCENIV does not contain sucrose.

Interactions with medicines. ASCENIV can make vaccines (like measles, mumps, rubella, and chicken pox vaccines) less effective in your body. Before you get any vaccines, tell your healthcare provider that you take ASCENIV.

What are other possible side effects of ASCENIV?

In clinical studies of ASCENIV, some patients experienced the following:

These are not all the possible side effects of ASCENIV.Talk to your healthcare provider about any side effect that bothers you or that does not go away.

You are encouraged to report side effects of prescription drugs to the FDA.Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.

Important Safety Information for ASCENIV™

WARNING: RISK OF BLOOD CLOTS (THROMBOSIS), POOR KIDNEY FUNCTION, AND INABILITY TO FILTER WASTE FROM KIDNEYS. BLOOD CLOTS MAY OCCUR WITH INTRAVENOUS IMMUNE GLOBULIN PRODUCTS, INCLUDING ASCENIV.Before taking ASCENIV, talk to your doctor if you:

Are of advanced age

Are unusually sedentary (long periods of sitting down or inactive)

Are taking estrogen-containing medicines (birth control pills, hormone replacement therapy)

Have a permanent intravenous (IV) catheter

Have hyperviscosity of the blood (diseases such as multiple myeloma or other causes of elevated proteins in the blood)

Have cardiovascular (heart) problems or previous history of stroke

Thrombosis may occur even if you do not have any risk factors.

Serious kidney problems and death can also happen in certain patients who receive such products.

If you are at high risk of thrombosis or kidney problems, your doctor should adjust the dose of ASCENIV and will monitor you for signs and symptoms of thrombosis and viscosity, as well as kidney function.

WARNING: RISK OF BLOOD CLOTS (THROMBOSIS), POOR KIDNEY FUNCTION, AND INABILITY TO FILTER WASTE FROM KIDNEYS. BLOOD CLOTS MAY OCCUR WITH INTRAVENOUS IMMUNE GLOBULIN PRODUCTS, INCLUDING ASCENIV.

Before taking ASCENIV, talk to your doctor if you:

ASCENIV (immune globulin intravenous, human-slra) is a prescription medicine to help adults and adolescents (12 to 17 years old) with primary immunodeficiency fight and prevent infections.
ASCENIV is for intravenous administration only. ASCENIV is made from healthy human blood/plasma.

These are not all the possible side effects of ASCENIV.
Talk to your healthcare provider about any side effect that bothers you or that does not go away.

You are encouraged to report side effects of prescription drugs to the FDA.
Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.

WARNING: RISK OF BLOOD CLOTS (THROMBOSIS), POOR KIDNEY FUNCTION, AND INABILITY TO FILTER WASTE FROM KIDNEYS. BLOOD CLOTS MAY OCCUR WITH INTRAVENOUS IMMUNE GLOBULIN PRODUCTS, INCLUDING ASCENIV.

Before taking ASCENIV, talk to your doctor if you: