Clinical presentation varies across patient populations1

Primary immunodeficiency diseases (PIDs) consist of a diverse group of over 300 diseases, some of which are associated with B- and T-cell deficiencies that negatively impact the immune system.1-4

Some of the risk factors that complicate the approach to PID and impact survival include3:

  • Recurrent respiratory infections that lead to impaired or irreparable lung function5
    • Asthma/COPD
    • Chronic sinusitis
    • Bronchiectasis
  • Excessive use of antibiotics that may lead to the development of more virulent and resistant organisms6
  • Each year of increase in age at diagnosis, environmental factors, and history of infection7,8
Despite standard immunue globulin therapy, patients continue to experience recurrent respiratory infectiona and chronic lung disease
Other factors that could lead to infection include inflammatory disease, malabsorption, granulomatous disease, liver diseases, including hepatitis, lymphoma, and other cancers.7